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As a hunger suppressant, nicotine seems to follow up on a piece of the cerebrum called the nerve center, at any rate in mice, as uncovered in an investigation by Yale specialists distributed in the June 10, 2011, issue of the diary Science

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Understanding how long a cannabis high lasts and how cannabinoid delivery routes affect onset and duration is relevant context here, because the same logic applies to nicotine: faster absorption through the nasal route means faster onset, and faster onset is directly connected to reinforcement strength